| Product revenues, net | 363.71a | 305.21a | 245.36a |
| Operating expenses | — | — | — |
| Cost of product revenues (excluding amortization of intangible assets) | -85.74a | -65.57a | -55.13a |
| Research and development | -598.37a | -571.01a | -397.52a |
| Selling, general and administrative | -461.12a | -344.5a | -265.78a |
| Amortization of intangible assets | -5.05a | -5.05a | -5.05a |
| Change in fair value of deferred and contingent consideration liabilities | -91.68a | -28.7a | -20.8a |
| Total operating expenses | -1,241.96a | -1,014.83a | -702.68a |
| Operating loss | -878.25a | -709.63a | -457.32a |
| Investment income | 53.31a | 42.13a | 11.08a |
| Interest expense | -84.91a | -81.69a | -26.45a |
| Change in fair value of interest rate swap | -0.24a | 0.32a | -1.53a |
| Other income (expense), net | 0.03a | 1.86a | -5.94a |
| Loss before income taxes | -910.07a | -747.01a | -480.15a |
| Provision for income taxes | -3.71a | -2.56a | -1.38a |
| Net loss | -913.77a | -749.57a | -481.53a |