| Revenue | — | — | — |
| Product revenue | 246.82a | 224.63a | 227.07a |
| Royalties | 226.17a | 150.11a | 139.82a |
| Contract and other revenue | 83.64a | 86.38a | 87.91a |
| Total revenue | 556.62a | 461.12a | 454.79a |
| Cost of revenue | — | — | — |
| Cost of product revenue | -95.88a | -84.5a | -88.98a |
| Cost of contract and other revenue | -3.03a | -5.4a | -4.67a |
| Amortization of acquired intangible assets | -11.2a | -13.52a | -13.94a |
| Total cost of revenue | -110.11a | -103.42a | -107.58a |
| Gross profit | 446.52a | 357.7a | 347.21a |
| Operating expenses | — | — | — |
| Research and development | -162.88a | -156.83a | -158.77a |
| Sales, general and administrative | -104.09a | -108.15a | -106.72a |
| Amortization of acquired intangible assets | -0.51a | -1.22a | -1.67a |
| Restructuring and other charges | | -9.37a | |
| Gain on divestiture | | -90.78a | |
| Impairment of assets | -1.07a | -10.05a | |
| Change in fair value of earn-out liability | -5.04a | 9.23a | 3.11a |
| Total operating expenses | -263.51a | -204.06a | -270.27a |
| Operating income | 183.01a | 153.64a | 76.94a |
| Interest income and other income (expense), net | 18.45a | 11.33a | 7.77a |
| Gain on sale of equity security | | | 3.55a |
| Loss on extinguishment of debt | | | -83.63a |
| Loss on fair value adjustment of derivatives, net | | -0.24a | -10.59a |
| Gain on sale of non-marketable equity security | | 23.92a | |
| Interest expense | -1.42a | -1.49a | -1.87a |
| Interest and other income (expense), net | 17.03a | 33.52a | -84.77a |
| Income (loss) before income taxes | 200.04a | 187.16a | -7.83a |
| Provision for (benefit from) income taxes | -20.22a | -146.74a | -6.49a |
| Net income (loss) | 179.82a | 333.9a | -14.31a |