| Revenues | — | — | — |
| Product revenues, net | 3,618.89a | 3,165.17a | 2,746.9a |
| Product royalty revenues | 579.33a | 523.48a | 482.74a |
| Milestone and contract revenues | 43a | 7a | 165a |
| Total revenues | 4,241.22a | 3,695.65a | 3,394.64a |
| Costs, expenses and other | — | — | — |
| Cost of product revenues (including definite-lived intangible amortization) | -312.07a | -254.99a | -207a |
| Research and development | -2,606.85a | -1,627.59a | -1,585.94a |
| Selling, general and administrative | -1,242.16a | -1,161.29a | -1,002.14a |
| Loss on change in fair value of acquisition-related contingent consideration | -19.8a | -29.2a | -12.15a |
| (Profit) and loss sharing under collaboration agreements | -1.03a | 2.05a | 7.97a |
| Total costs, expenses and other | -4,179.85a | -3,075.12a | -2,815.2a |
| Income from operations | 61.37a | 620.53a | 579.44a |
| Interest income | 128.71a | 158.41a | 40.45a |
| Interest expense | -2.28a | -2.55a | -2.67a |
| Realized and unrealized gain (loss) on equity investments | 116.03a | 43.89a | -87.59a |
| Other, net | 12.81a | 13.93a | -0.52a |
| Income before provision for income taxes | 316.63a | 834.22a | 529.12a |
| Provision for income taxes | -284.02a | -236.62a | -188.46a |
| Net income | 32.62a | 597.6a | 340.66a |