| Revenues | — | — | — |
| Product sales | 285.42a | 180.41a | 118.93a |
| Royalty revenue | 274.82a | 182.65a | 21.69a |
| Collaboration and license | 0a | 71.18a | 222.71a |
| Total revenues | 560.23a | 434.25a | 363.33a |
| Operating expenses | — | — | — |
| Cost of sales | -76.73a | -45.21a | -28.32a |
| Research and development | -697.87a | -648.45a | -705.79a |
| Selling, general and administrative | -321.61a | -309.8a | -278.14a |
| Total operating expenses | -1,096.2a | -1,003.46a | -1,012.25a |
| Loss from operations | -535.97a | -569.21a | -648.92a |
| Interest income | 36.51a | 26.69a | 11.07a |
| Change in fair value of equity investments | -1.12a | 0.4a | -19.3a |
| Non-cash interest expense on liabilities for sales of future royalties | -63.04a | -66a | -43.02a |
| Other expense | -3.96a | -0.34a | -1.57a |
| Loss before income taxes | -567.59a | -608.46a | -701.73a |
| (Provision for) benefit from income taxes | -1.6a | 1.83a | -5.7a |
| Net loss | -569.18a | -606.64a | -707.42a |