| Revenues | — | — | — |
| Royalties | 570.99a | 447.87a | 360.48a |
| Product sales, net | 303.49a | 300.85a | 191.03a |
| Revenues under collaborative agreements | 140.84a | 80.53a | 108.61a |
| Total revenues | 1,015.32a | 829.25a | 660.12a |
| Operating expenses | — | — | — |
| Cost of sales | -159.42a | -192.36a | -139.3a |
| Amortization of intangibles | -71.05a | -73.77a | -43.15a |
| Research and development | -79.05a | -76.36a | -66.61a |
| Selling, general and administrative | -154.34a | -149.18a | -143.53a |
| Total operating expenses | -463.85a | -491.68a | -392.59a |
| Operating income | 551.48a | 337.57a | 267.53a |
| Other income (expense) | — | — | — |
| Investment and other income, net | 23.75a | 16.32a | 1.05a |
| Inducement expense related to convertible notes | 0a | 0a | -2.71a |
| Contingent liability fair value measurement gain | 0a | 13.2a | 0a |
| Interest expense | -18.1a | -18.76a | -16.95a |
| Income before income tax expense | 557.13a | 348.33a | 248.92a |
| Income tax expense | -113.04a | -66.74a | -46.79a |
| Net income | 444.09a | 281.59a | 202.13a |