| Revenues | — | — | — |
| Net product revenue | 600.95a | 661.25a | 535.23a |
| Collaboration revenue | 0.3a | 100.03a | 50.05a |
| Royalty revenue | 203.86a | 168.86a | 113.52a |
| Manufacturing revenue | 1.66a | 7.69a | 0a |
| Total revenues | 806.78a | 937.82a | 698.8a |
| Operating expenses | — | — | — |
| Cost of product sales, excluding amortization of acquired intangible assets | -57.4a | -65.49a | -44.68a |
| Amortization of acquired intangible assets | -60.74a | -222.64a | -116.55a |
| Research and development | -534.48a | -666.56a | -651.5a |
| Selling, general and administrative | -300.91a | -332.54a | -326a |
| Change in the fair value of contingent consideration | -4.48a | -127.7a | -25.9a |
| Intangible asset impairment | -159.55a | -217.8a | -33.38a |
| Tangible asset impairment and losses (gains) on transactions, net | -0.75a | 0a | 0a |
| Total operating expenses | -1,109.35a | -1,377.32a | -1,146.21a |
| Loss from operations | -302.57a | -439.5a | -447.41a |
| Interest expense, net | -166.99a | -129.18a | -90.87a |
| Other income (expense), net | 6.54a | 10.13a | -49.21a |
| Gain on sale of priority review voucher | 99.9a | 0a | 0a |
| Loss on extinguishment of debt | 0a | -137.56a | 0a |
| Loss before income tax (expense) benefit | -363.12a | -696.11a | -587.49a |
| Income tax (expense) benefit | -0.18a | 69.51a | 28.47a |
| Net loss attributable to common stockholders | -363.3a | -626.6a | -559.02a |